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Solubility Enhancement of Nebivolol by Micro Emulsion Technique

1★, 2★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, ShriJagdish Prasad JhabarmalTibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, INDIA.
  2. 2Department Pharmacognosy, Govt. College of Pharmacy, Amravati, INDIA.

CORRESPONDENCE

Santosh Kale Nemichand

Department of Pharmaceutical Sciences, ShriJagdish Prasad JhabarmalTibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, INDIA.

sharudeore_2@yahoo.com

Volume 8, Issue 4 · pp. 356-367 · 2016 · DOI: 10.5530/jyp.2016.4.11

ABSTRACT

Nebivolol is a third-generation beta-a drenoceptor antagonist. It differs from other beta-a drenoceptor an tagonists as it combines highly selective beta (1)-adrenoceptor antagonist properties with nitric oxide-mediated vasodilator actions and beneficial effects on endothelial function. But this very useful drug use is limited due to challenge of poor water solubility (0.0403 mg/ml). Present study deals with enhancement of solubility of Nebivolol by micro emulsion technique. Various oils, surfactants, and co-surfactants were used to check solubility of Nebivolol. Pseudoternary phase diagrams were constructed using various combinations of ingredients i.e. oil: surfactant: co-surfactant. Micro emulsion batches were prepared by phase titration method. Developed micro emulsion was evaluated for various physicochemical, stability parameters, in-vitro and ex-vivo parameters. Results showed stable micro emulsion form of Nebivololimproved solubility.

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    Nemichand, S. K., & Laxman, S. D. (2016). Solubility Enhancement of Nebivolol by Micro Emulsion Technique. Journal of Young Pharmacists, 8(4), 356-367. https://doi.org/10.5530/jyp.2016.4.11

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0