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Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel

1,2, 1, 1★★ Corresponding author

  1. 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.
  2. 2Department of Pharmaceutics, College of Pharmacy, Hail University, KSA.

CORRESPONDENCE

Azza Ali Hasan

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.

azzahasan_7@hotmail.com

Volume 8, Issue 4 · pp. 335-340 · 2016 · DOI: 10.5530/jyp.2016.4.8

ABSTRACT

Objective: The aim of this study is to formulate and evaluate proniosomal gel formulations as transdermal delivery systems of glimepiride (GM) to improve its therapeutic efficacy.Methods: Proniosomal formulations have been prepared using different types of non-ionic surfactants with cholesterol in different molar ratios. Proniosomal gel; PN16 (Span 60, Tween 60, Cholesterol; 35:35:30 molar ratio) that exhibits maximum EE % (94.01 ± 0.88) and most prolonged release was chosen forex-vivo skin permeation andin-vivo hypoglycemic activity studies.Results: Proniosomal gel produced better permeation through rabbit skin than HPMC niosomal gel and HPMC gel. The pharmacokinetic parameters; time of maximum response (Tmax), % reduction in blood glucose concentration and area above the blood glucose levels-time curve (AAC) of proniosomal gel were studied. Proniosomal gel showed a controlled release behavior and a significantly higher hypoglycemic activity (65.34 ± 6.54%).Conclusion: It is evident from this study that proniosomal gel can act as an alternative approach for enhancing transdermal delivery of GM.

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    Abdallah, M. H., Sabry, S. A., & Hasan, A. A. (2016). Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel. Journal of Young Pharmacists, 8(4), 335-340. https://doi.org/10.5530/jyp.2016.4.8

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0