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Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives

1,5★, 2, 3, 4, 1,5★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.
  2. 2Meerut Institute of Engineering and Technology (MIET), NH-58 Meerut-Delhi Bypass, Meerut, Uttar Pradesh, INDIA.
  3. 3Innovative College of Pharmacy, Knowledge Park-ii, Greater Noida, Uttar Pradesh, INDIA.
  4. 4Department of Chemistry, Faculty of Sciences, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.
  5. 5Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.

CORRESPONDENCE

Prince Prashant Sharma

Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.

princeb4me@rediffmail.com

Volume 8, Issue 4 · pp. 319-323 · 2016 · DOI: 10.5530/jyp.2016.4.5

ABSTRACT

Objective: The present study projected to the synthesis of 3b-Hydroxy-lup- 20(29)-en-28-oic acid analogues in order to evaluate their possible biological activity. In addition, the structure–activity relationship is also investigated.Method: BA derivatives were prepared by conjugating 3b-Hydroxy-lup- 20(29)-en-28-oic acid with different amines through carbomyl linkage. Structures of synthesized compounds were elucidated by spectral data. Cytotoxic evaluation was done by CAM assay and MTT assay.Results: Among the synthesized compounds, Compound 7showed a pronounced cytotoxicity in antiangiogenic assay as well as compound ECV-304 cell line. Compound 10 also showed good cytotoxic activity. While compounds 6 and 8 showed moderate activity against A-549 and MCF-7 respectively.Conclusion: It is concluded that synthesized BA analogues are biologically active and developed into useful anticancer agents.

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    Sharma, P. P., A, A., Roy, R. K., Kaushik, R. D., & Sharma, V. K. (2016). Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives. Journal of Young Pharmacists, 8(4), 319-323. https://doi.org/10.5530/jyp.2016.4.5

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0