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Ataxia, Manifestation of Phenytoin Toxicity: A Case Report

1, 1, 2, 3, 4★, 4★ Corresponding author

  1. 1Department of Pharmacy Practice, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, INDIA.
  2. 2Patient Safety Pharmacovigilance Associate, National Co-ordination Centre, PvPI, Indian Pharmacopoeia Commission, Ghaziabad, Uttar Pradesh, INDIA.
  3. 3Department of Pharmacy Practice, JSS College of Pharmacy, Mysuru, Karnataka, INDIA.
  4. 4Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Punjab, INDIA.

CORRESPONDENCE

Chhabra Manik

Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Punjab, INDIA.

manikchhabra57@gmail.com

Received: 28-06-2018; Revised: 30-09-2018; Accepted: 20-10-2018.

Volume 11, Issue 1 · pp. 112-113 · 2019 · DOI: 10.5530/jyp.2019.11.24

ABSTRACT

Phenytoin is a choice of drug for the treatment of epilepsy. It is categorized under drugs with narrow therapeutic range. Adverse effects of phenytoin observed in patients are gum hypertrophy, dystonia, myoclonus, abnormal muscle movement and rarely ballismusand ataxia. We report a case of a 32-year-old female, who had chief complaints of ataxia, oscillopsia, dizziness and nausea. She had past medical history of epilepsy and was taking phenytoin from the past 10 years. Treatment was started after tapering the dose of phenytoin, finally discontinuing, she was prescribed with valproic acid as an alternative for phenytoin. Present case report describes the phenytoin toxicity that helps to create awareness among physicians. There should be proper monitoring of plasma concentration of phenytoin to avoid its toxicity in the patients on chronic drug therapy so that drug dosage can be tailored as per the pharmacokinetic needs of the patient.

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    Juhi, S., Singh, T. S., Singh, J. M., Muhammed, R., Manik, C., & Kumar, T. R. (2019). Ataxia, Manifestation of Phenytoin Toxicity: A Case Report. Journal of Young Pharmacists, 11(1), 112-113. https://doi.org/10.5530/jyp.2019.11.24

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    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0