Synthesis, Anti-inflammatory and Antioxidant Activity of Mannich Bases of Dehydrozingerone Derivatives
1★, 1, 1, 1, 1, 1, 1, 1, 1★ Corresponding author
- 1Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.
CORRESPONDENCE
Hayun Hayun
Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.
Received: 29-11-2017; Revised: 28-01-2018; Accepted: 12-03-2018.
Volume 10, Issue 2s · pp. S6-S10 · 2018 · DOI: 10.5530/jyp.2018.2s.2
ABSTRACT
Objectives: This study aims to synthesize a series of five new Mannich bases of dehydrozingerone (DHZ) derivatives and to evaluate for their antiinflammatory and antioxidant activity.Materials and Methods: The synthesis was performed by refluxing DHZ with formaldehyde and secondary amines, and the structures of the synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR, and HR-MS. The anti-inflammatory and antioxidant activity evaluations were done by inhibition of heat-induced albumin denaturation and a free-radical DPPH method, respectively.Results: All the synthesized compounds (2a-e) showed anti-inflammatory and antioxidant activity. The highest anti-inflammatory activity was shown by compound 2c. The activity was comparable to the that of diclofenac sodium as a standard. While, the highest antioxidant activity was demostrated by compound 2e. The compound showed moderate activity compared to that of quercetin as a standard. Mostly of Mannich base derivatives of DHZ compounds exhibited higher antioxidant activity than that of DHZ.Conclusion:A series of five new Mannich bases of DHZ (2a-e) was synthesized successfully. Compound 2c demonstrated anti-inflammatory activity which was comparable to diclofenac sodium, while compound 2e exhibited moderate antioxidant activity compared to quercetin as standard.
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Hayun, H., Arrahman, A., Purwati, E. M., Yanuar, A., Fortunata, F., Suhargo, F., Syafiqah, D. W., Ignacia, C., & Novalia, A. R. (2018). Synthesis, Anti-inflammatory and Antioxidant Activity of Mannich Bases of Dehydrozingerone Derivatives. Journal of Young Pharmacists, 10(2s), S6-S10. https://doi.org/10.5530/jyp.2018.2s.2
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