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Comparison of the Characteristics of Transfersomes and Protransfersomes Containing Azelaic Acid

1★, 1, 1★ Corresponding author

  1. 1Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.

CORRESPONDENCE

Iskandarsyah I

Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.

aya_2803@yahoo.com

Received: 21-12-2017; Revised: 28-01-2018; Accepted: 12-03-2018.

Volume 10, Issue 2s · pp. S11-S15 · 2018 · DOI: 10.5530/jyp.2018.2s.3

ABSTRACT

Objectives: Recently developed agent carriers, transfersomes, which are sufficiently deformable to penetrate into or across the skin barrier. Protransfersome is the lyophilization of transfersome by removing the water system with freeze-drying method to improve the protransfersome characterizations, especially entrapment efficiency. The aim of this study was to comparethe characteristics ofazelaic acid transfersomes and protransfersomes.Materials and Methods: Transfersome was prepared by thin layer hidration method. Protransfersome was prepared by freeze-drying method and trehalose as lyoprotectant. The characterizations that measured were entrapment efficiency, morphological structure, particel size, and zeta potential.Results: The result of Transfersome particel size characterization, pointed out measurement with 89,06 nm. Whereas, after freeze- drying process, Protransfersome A has 735 nm, Protransfersome B has 1218 nm, and Protransfersome C has723,1 nm. There are excalations from 40,98% of entrapment efficiency after freeze-drying process, Protransfersome A with percentage 45,20%, Protransfersome B with percentage 45,65%, and Protransfersome C with percentage 52,90%. The spheric vesicle morphology of transfersome and protransfersomes is determined by transmission electron microscope.Conclusion: Protransfersomes have a better stability in entrapment efficiency by using trehalose or no trehalose with indirect cooling rate within 4 weeks of storage period. Key message: There has been no research yet that compares the stability of azelaic acid transfersome to protransfersome of azelaic acid which uses freeze-drying method with three different steps, which are fast-freezing trehalose step, slow-freezing trehalose step, and slow-freezing step without trehalose.

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    I, I., Rahmi, A. D., & Pangesti, D. M. (2018). Comparison of the Characteristics of Transfersomes and Protransfersomes Containing Azelaic Acid. Journal of Young Pharmacists, 10(2s), S11-S15. https://doi.org/10.5530/jyp.2018.2s.3

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    © 2018 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0