Journal of Young Pharmacists logo
Submit
Journal of Young PharmacistsACADEMIC PUBLISHING
Article

Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia

1★, 1, 1, 1★ Corresponding author

  1. 1Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA.

CORRESPONDENCE

Pozdnyakov DI

Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA.

pozdniackow.dmitry@yandex.ru

Received: 18-11-2017; Revised: 30-12-2017; Accepted: 08-01-2018.

Volume 10, Issue 2 · pp. 193-196 · 2018 · DOI: 10.5530/jyp.2018.10.43

ABSTRACT

Objective: To assess the effect of 4-hydroxy-3,5-di-tret-butyl cinnamic acid on the state of endothelial function under conditions of experimental cerebral ischemia.Materials and Methods: Antioxidant properties of 4-hydroxy-3,5-di-tret-butyl cinnamic acid and the effect of this compound on NO-synthase system activity and ADMA concentration were evaluated.Results: As a result, it has been found that the use of 4-hydroxy-3,5-di-tretbutyl cinnamic acid promotes reduction activity of catalase, glutathione peroxidase, superoxide dismutase and a decrease in the concentration of MDA and DC. In addition, the ability to modulate NO synthase system activity was established for this compound: an increase in eNOS activity by 114.2% (p <0.05), decrease activity of nNOS and iNOS by 60.6% (p <0.05) and 61.9% (p <0.05), respectively, decrease concentration of ADMA by 83.9% (p <0.05).Conclusion: The results of the conducted researches it is established that 4-hydroxy-3,5-di-tret-butyl cinnamic acid has antioxidant and NOS – regulating effect.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    DI, P., AV, V., DS, Z., & AV, A. (2018). Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia. Journal of Young Pharmacists, 10(2), 193-196. https://doi.org/10.5530/jyp.2018.10.43

    Copyright and licence

    © 2018 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0