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Evaluation of the Antifungal Effect Vitis vinifera Extract on Candida albicans

1, 1, 2, 3, 1, 1, 4, 1, 1, 1, 1, 1

  1. 1Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, CE, BRAZIL.
  2. 2Dentistry College State University of Rio de Janeiro, UERJ, Rio de Janeiro, RJ, BRAZIL.
  3. 3State University of Ceara, UECE, Fortaleza, CE, BRAZIL.
  4. 4Paulo Picanço College of Dentistry, Fortaleza, CE, BRAZIL.

CORRESPONDENCE

Received: 14-07-2017; Revised: 31-07-2017; Accepted: 19-08-2018.

Volume 10, Issue 2 · pp. 164-168 · 2018 · DOI: 10.5530/jyp.2018.10.37

ABSTRACT

Objective: This research analyzed in vitro the antifungal activity of the solution composed by grapes seed extract Vitis vinifera (Doctor’s A-Z®) against Candida albicans (ATCC 20231) species aiming to determine the minimum inhibitory concentration (MIC) and minimum fungicide concentration (MFC).Methods: To that, were used micro dilution boards of 96 wells where the strain of Candida. Was tested the diluted solutions in distilled water on the concentrations 0.20 g/mL, 0.30 g/mL and 0.40 g/mL. As growing control were used growing fungous, to test the viability of the strains. As positive control, was used nystatin (commercial suspension 100,000 UI/mL) and as sterility control of growing way. The tests were conducted in triplicate and the data obtained were analyzed through the exam Kruskal-Wallis, with significance level of 95% (p<0.05).Results: The results indicated that all the samples were sensible to the analyzed extract and the CIM was obtained with the solution of 0.30 g/mL (30%). However, wasn’t observed a fungicide effect (MFC) on the tested concentrations.Conclusion: We conclude that the grapes seed extract can be an alternative against the gender Candida, however are necessary larger studies to prove their ant fungous action.

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    Gadelha, L. M. U., Valadas, L. A. R., Fiallos, N. D. M., Peralta, S. L., Mendonça, K. S., Lotif, M. A. L., Bezerra, G. L., Aguiar, M. G. L. D., Diógenes, É. S. G., Neto, E. M. R., Asevedo, G. O., & Fiallos, A. C. D. M. (2018). Evaluation of the Antifungal Effect Vitis vinifera Extract on Candida albicans. Journal of Young Pharmacists, 10(2), 164-168. https://doi.org/10.5530/jyp.2018.10.37

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    © 2018 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0