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Quantitative Estimation of Efavirenz by High Performance Thin Layer Chromatography

1★, 1, 1★ Corresponding author

  1. 1Department of Pharmaceutical Analysis, Prin. K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai, INDIA.

CORRESPONDENCE

Hamrapurkar P

Department of Pharmaceutical Analysis, Prin. K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai, INDIA.

phamrapurkar@gmail.com

Volume 1, Issue 4 · pp. 359-363 · 2009 · DOI: 10.4103/0975-1483.59328

ABSTRACT

A simple, accurate, and precise HPTLC method has been developed and validated for the estimation of efavirenz from bulk drug and capsule formulations. The separation was achieved on TLC plates using an appropriate solvent system. The spots so developed were densometrically scanned at 247 nm. The linearity of the method was found to be within the concentration range of 1-40 µg/ml. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of this method. The method was successfully applied for determination of drug in capsules, wherein no interference from capsule excipients was observed, indicating the speciÞ city of the developed method. Thus, the proposed method can be used successfully for routine analysis of efavirenz from capsule and bulk formulations.

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    P, H., M, P., & N, S. (2009). Quantitative Estimation of Efavirenz by High Performance Thin Layer Chromatography. Journal of Young Pharmacists, 1(4), 359-363. https://doi.org/10.4103/0975-1483.59328

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0