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A Validated Method for Development of Tenofovir as API and Tablet Dosage Forms by UV Spectroscopy

1★, 2, 3, 1, 1, 1★ Corresponding author

  1. 1Division of Pharmaceutical Sciences, INDIA.
  2. 2Department of Chemistry, Shri Guru Ram Rai Institute of Technology and Sciences, Patel Nagar, Dehradun-248001, Uttarakhand, INDIA.
  3. 3Department of Pharmacy, Kumoun University, Bhimtal, Nainital, INDIA.

CORRESPONDENCE

Gnanarajan G

Division of Pharmaceutical Sciences, INDIA.

Volume 1, Issue 4 · pp. 351-353 · 2009 · DOI: 10.4103/0975-1483.59326

ABSTRACT

A simple new spectrophotometric method has been developed for estimation of Tenofovir disoproxil fumarate in bulk and tablet dosage form. Tenofovir disoproxil fumarate is estimated to be 261 nm in triple distilled water. The Beer’s law is obeyed in the concentration range of 5 – 90 µg/mL of the drug. The slope and intercept values are 0.0109 and 0.1075, respectively. Results of analysis of this method have been validated statically and by recovery studies. The method is applied to the marketed tablet formulation. A result of the analysis of tablet formulation, given as a percentage of label claim ± standard deviation is 98.15 ± 0.76. The precision and accuracy has been examined by performing recovery studies and found to be 100.06 ± 1.24. The developed method is simple, sensitive, and reproducible, and can be used for the routine analysis of Tenofovir disoproxil fumarate in bulk and tablet dosage form.

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    G, G., AK, G., V, J., P, K., PK, Y., & P, K. (2009). A Validated Method for Development of Tenofovir as API and Tablet Dosage Forms by UV Spectroscopy. Journal of Young Pharmacists, 1(4), 351-353. https://doi.org/10.4103/0975-1483.59326

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0