Volume 18, Issue 2

K Joshna, Sandhya M J Nair, S Mathan

pp. 244-250 · DOI: 10.5530/jyp.20260344 · 2026

Thiazolidinediones are a class of five-membered heterocyclic compounds that have gained significant attention in medicinal chemistry due to their diverse therapeutic potential. These compounds, characterized by the prese…

M K Soumya, R. Margret Chandira, Sujith S Nair

pp. 251-259 · DOI: 10.5530/jyp.20260328 · 2026

Drug Related Problems (DRP) represent a significant and often under-recognised challenge in the care of elderly patients admitted to Intensive Care Units (ICU). Epidemiological data reveal a high prevalence of DRP among …

Kannaiyan Suria Prabha, Joshua Albert, Daniel Catherine Grace, Selva Kumar Gokul, Sankar Kalai Kumar, Ganesan Shyam Sundar, Ravichandran Udaya Kumar

pp. 260-266 · DOI: 10.5530/jyp.20260217 · 2026

Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory condition that is marked by sustained synovial inflammation, joint destruction, and extra-articular complications. While methotrexate and other conventional …

Kausendra Singh, Anurag Verma

pp. 267-274 · DOI: 10.5530/jyp.20260403 · 2026

Background: As the nail plate is not very permeable and has a high density of keratinization, onychomycosis is one of the most common types of mycological nail contamination and is characterized by high recurrence. Despi…

Biswajit Das, Radhakrishnan Narayanaswamy, KR Shruthi, Wilma Delphine Silvia Chickballapur Rayappa, BS Sachin, Arbind Kumar Choudhary

pp. 275-285 · DOI: 10.5530/jyp.20260318 · 2026

Diabetic Kidney Disease (DKD) is the leading cause of end-stage renal disease worldwide, yet routine clinical biomarkers-albuminuria and creatinine-based estimated Glomerular Filtration Rate (eGFR)-often change only afte…

Pawan Banduji Itankar, Gaurav Rajendra Sawarkar, Punam Gaurav Sawarkar, Vaishnavi Banduji Itankar, Kamlesh Surendra Choudhary

pp. 286-292 · DOI: 10.5530/jyp.20260324 · 2026

Ehretia laevis Roxb., a medicinal tree from the Boraginaceae family, has been a cornerstone of traditional medicine across Asia for treating a multitude of ailments, particularly those involving inflammation and tissue d…

S Sindhu, K. Sujatha, S Bhuvana, C. D. Mohanapriya, M. G. Rajanandh

pp. 293-299 · DOI: 10.5530/jyp.20260343 · 2026

Metabolic Syndrome (MetS) encompasses central obesity, insulin resistance, dyslipidemia, and hypertension, collectively increasing risks of cardiovascular disease and type 2 diabetes. Menopause exacerbates susceptibility…

Sekhar Sharma, Bhumika Chettri, R Keerthi Shree, G Namana, N P Rakshitha, Benson Babu Thomas, B Sreya Krishna, V V Suryan, Rajendra Dhakal

pp. 300-309 · DOI: 10.5530/jyp.20260026 · 2026

Background: Cellular senescence is a condition in which the cells permanently stop dividing due to various conditions like DNA damage, shortening of telomeres, oxidative stress, and mitochondrial problems. Initially this…

Piyali Khamkat, Vivek Barik, Soudip Das, Rupam Maiti, Soumen Singh, Sangita Banerjee, Siddheswar Maiti, Prasenjit Mondal

pp. 310-314 · DOI: 10.5530/jyp.20260032 · 2026

Aquasomes, a novel Vesicular Drug Delivery (VDD) technology in the pharmaceutical industry, are composed of a three-layered self-assembled nanoparticle (NP) such as a ceramic core, carbohydrate coating, and drug. It adso…

Kavitha Chrisnasamy, Nur Jahan Ahmad

pp. 315-324 · DOI: 10.5530/jyp.20260282 · 2026

Ocean education has become an increasingly important field in addressing global environmental and sustainability challenges. A comprehensive analysis is presented of its current landscape, exploring recent innovations, p…

Anitha Singarakani, Prakash Ramakrishnan

pp. 325-350 · DOI: 10.5530/jyp.20260013 · 2026

Background: This research paper aims to establish comprehensive pharmacognostical standards and DNA barcode markers for Pergularia daemia (Forssk.) Chiov., a medicinally important plant in traditional medicine systems. P…

Gomathi Ramalingam, Uma Maheswari T Natarajasundaram, Rajesh Kumar Shanmugam

pp. 351-356 · DOI: 10.5530/jyp.20260339 · 2026

Background: Cancer patients frequently experience oral mucositis and oral candidiasis, which are frequently associated with oral pathogens like Candida albicans and Streptococcus mutans. The increasing prevalence of anti…

Pughazendhi Ravi, Chandrasekaran Velusamy Subbaraman, Muthukumaran Mylasalam, Gowrishankar Jayabalan, Santhiya Gopalsamy, Nivetha Jasmine Edwardraj

pp. 357-368 · DOI: 10.5530/jyp.20260033 · 2026

Background: Breast cancer is a biologically heterogeneous disease driven by complex and interconnected molecular pathways, often limiting the efficacy of conventional single-target therapies. Purpose: In this study, an i…

Karthikeyan Sathasivam, Subramanian Somaskanthan, S. M. Habibur Rahman

pp. 369-376 · DOI: 10.5530/jyp.20260057 · 2026

Background: Colorectal Cancer (CRC) therapy is limited by poor tumor selectivity and systemic toxicity associated with 5-Fluorouracil (5-FU). Liquid Crystalline Nanoparticles (LCNs) offer sustained drug release and impro…

Parag Ashok Pathade, Kalyani Jaywant Bhor, Shivraj Popat Jadhav, Yogesh Suresh Ahire, Vinod Ahshok Bairagi, Bhaskar Onkar Aher, Shakeeb Akhtar Nehal Ahmad

pp. 377-385 · DOI: 10.5530/jyp.20260390 · 2026

Background: Rifaximin is a poorly water-soluble antibiotic that limits dissolution, formulation flexibility, and topical delivery. Enhancing its solubility is essential to improve therapeutic performance in localized app…

Varadharajan Sivaraman, Natarajan Shanmugasundaram, Kannan Lakshminarayanan, Thamilselvan Palanichamy, Harshitha Muthu Sundaram, Karthik Sankarbabu

pp. 386-391 · DOI: 10.5530/jyp.20260085 · 2026

Background: Delusions in schizophrenia are characterized by rigidity and resistance to change; processes potentially linked to metacognitive deficits. However, there is a lack of specific tools to assess metacognitive be…

Sanjay Ugare, Vinaya Gidaballi, Sachin Gudasi, Tejaswini Chougala, Shweta Myagadeyavar, K.L. Krishna

pp. 392-398 · DOI: 10.5530/jyp.20260240 · 2026

Background: Tinospora cordifolia is a renowned traditional medicinal herb known for its diverse therapeutic properties, including antioxidant, neuroprotective, and immunomodulatory effects. Materials and Methods: A hydro…

Dumpa Rushi Kumar Reddy, Suryaprakash Reddy Chappidi

pp. 399-408 · DOI: 10.5530/jyp.20260307 · 2026

Background: Parkinson's Disease (PD) is the second most prevalent neurodegenerative disorder. Currently levodopa along with MAO-B inhibitors remains first line therapy for the management of motor complications. However, …

Pawan Singh, Anuj Kumar, Pankaj Kumar, Arun Kumar, Mohd Fareed, Sunita Gangwar, Mohd Junaid

pp. 409-418 · DOI: 10.5530/jyp.20260404 · 2026

Background: Oral drugs like amlodipine besylate commonly have problems such as low water solubility and high first-pass metabolism, leading to changing plasma concentrations. Emulgel formulations offer a great solution a…

Chandrasekaran Velusamy Subbaraman, Muthukumaran Mylasalam, Pughazendhi Ravi, Manimegalai Karnan, Gowrishankar Jayabalan

pp. 419-428 · DOI: 10.5530/jyp.20260035 · 2026

Background: Pantoprazole sodium is a highly effective proton pump inhibitor that has continued to languish in the therapeutic armory against the acid in the gastrointestinal tract. However, its pharmacokinetic properties…