Design and evaluation of solid self-emulsifying drug delivery system of rosuvastatin calcium
1, 2, 1
- 1Department of Pharmaceutics, A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy, Vallabh Vidyanagar, Anand, Gujarat, INDIA.
- 2Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Anand, Gujarat, INDIA.
CORRESPONDENCE
Chirag Nagda
Department of Pharmaceutics, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Anand - 388 121, Gujarat, India.
Volume 6, Issue 3 · pp. 37-46 · 2014 · DOI: 10.5530/jyp.2014.3.7
ABSTRACT
Background: The work has been undertaken with an objective to prepare a self-emulsifying drug delivery system (SEDDS) of rosuvastatin calcium (ROS) with the least amount of surfactant which could enhance its solubility and oral bioavailability.Materials and Methods: Spectrophotometric method was used to estimate the solubility of the drug in various oils, surfactant and co-surfactant. The phase behavior and most efficient self-emulsifying region were identified by constructing pseudo ternary phase diagram. The solid-SEDDS (S-SEDDS) was prepared using an adsorbent consequently the prepared S-SEDDS were filled up in hard gelatin capsule which were evaluated for various physicochemical parameters.Results: The composition of optimized formulation consisted of 10 mg of ROS, capmul MCM (oil), cremophor ELP (surfactant) and propylene glycol (co-surfactant). The optimized formulation showed negative zeta potential (−22.11 mv), optimal particle size (10.59 nm) and demonstrated excellent self-emulsifying ability with a maximum solubilizing capability. The S-SEDDS formulations were prepared from the optimized liquid SEDDS, which revealed maximum release rate (97.7%) among all the prepared S-SEDDS formulation and marketed formulation.Conclusion: It was concluded that S-SEDDS prepared from liquid SEDDS can be a promising novel approach to enhance the solubility and drug release of ROS, which in turn also develops a stable formulation, least drugs leakage and precipitation than the liquid SEDDS.
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Rokad, V., Nagda, C., & Nagda, D. (2014). Design and evaluation of solid self-emulsifying drug delivery system of rosuvastatin calcium. Journal of Young Pharmacists, 6(3), 37-46. https://doi.org/10.5530/jyp.2014.3.7
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