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Anti-diabetic activities of (part) and fractions of Stereospermum tetragonum DC

1, 2, 2, 1★★ Corresponding author

  1. 1Division of Phytochemistry and Phytopharmacology, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, INDIA.
  2. 2Department of Ayurvedic Research, Sastra University, Tanjore, INDIA.

CORRESPONDENCE

Appian Subramoniam

Division of Phytochemistry and Phytopharmacology, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, INDIA.

asubramoniam@yahoo.com

Received: 11-04-2012; Revised: 12-05-2012; Accepted: 01-09-2012.

Volume 5, Issue 1 · pp. 7-12 · 2013 · DOI: 10.1016/j.jyp.2012.09.002

ABSTRACT

Objectives: To identify the active principles, determine the anti-diabetes activity of fraction of Stereospermum tetragonum root.Materials and Methods: The efficacy was evaluated in streptozotocin induced type 2 diabetic rats and the anti-hyperglycemic activity was studied by glucose tolerance test. The major active compounds were isolated by solvent fractionation and chromatographic techniques and characterized with spectral data.Results: The active fraction of S. tetragonum showed presence of anti-diabetes mellitus activity in type-2 diabetic rats. It did not significantly influence insulin release from cultured islets. Two active principles (active at 2 mg/kg dose) were isolated and characterized with spectral data.One of themwas identified as an iridoid type glycoside and the other one was a lapachol like compound (derivative of naphthoquinone).Conclusions: Two active principles from the anti-diabetes fraction of S. tetragonum root were isolated and identified as an iridoid glycoside and a naphthoquinone derivative.

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    Kingsley, R. B., Mishra, M., Brindha, P., & Subramoniam, A. (2013). Anti-diabetic activities of (part) and fractions of Stereospermum tetragonum DC. Journal of Young Pharmacists, 5(1), 7-12. https://doi.org/10.1016/j.jyp.2012.09.002

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    © 2013 Author(s)

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