Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines
1, 2★, 3, 4★ Corresponding author
- 1Department of Chemistry, Islamic Azad University, Young Researchers Club, IRAN.
- 2Department of Chemistry, IRAN.
- 3Medicinal Sciences, Islamic Azad University, IRAN.
- 4Moravvej Student-Research Institute, Ardabil Branch, Ardabil, IRAN.
Volume 2, Issue 4 · pp. 399-402 · 2010 · DOI: 10.4103/0975-1483.71638
ABSTRACT
Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4[(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), N4-[(E)-2-phenylethylidene] (NPI), N4[(E,2E)-3-phenyl-2-propenylidene] (NPPI), and N4[(E) ethylidene] (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
F, S., S, G., A, J., & F, S. (2010). Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines. Journal of Young Pharmacists, 2(4), 399-402. https://doi.org/10.4103/0975-1483.71638
Copyright and licence
© 2010 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0