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Aqueous Extract of Garcinia indica Choisy Restores Glutathione in Type 2 Diabetic Rats

1, 2

  1. 1T.V.M. College of Pharmacy, Gandhinagar, Bellary-583103, Karnataka, INDIA.
  2. 2Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Sector-III, Pushp Vihar, New Delhi, INDIA.

CORRESPONDENCE

Srinivasan BP

Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Sector-III, Pushp Vihar, New Delhi, INDIA.

bpsrinivasan@yahoo.com

Volume 2, Issue 3 · pp. 265-268 · 2010 · DOI: 10.4103/0975-1483.66806

ABSTRACT

Significant depletion of glutathione (GSH-reduced form) was observed in type 2 diabetes due to oxidative stress. Hence the present study was aimed to investigate a drug which restores GSH along with its anti-diabetic activity. Aqueous extract of Garcinia indica at a dose of 100 mg/kg and 200 mg/kg was given orally to streptozotocininduced type 2 diabetic rats for a period of 4 weeks. At the end, parameters such as fasting blood glucose, postprandial blood glucose, and GSH in blood were analyzed. Aqueous extract of G. indica significantly decreased both the fasting and postprandial blood glucose in type 2 diabetic rats. The extract also restored the erythrocyte GSH in type 2 diabetic rats. Drug at higher dose, i.e. 200 mg/kg, had a more pronounced effect. Restoring the erythrocyte GSH, an intracellular anti-oxidant in diabetes, will be beneficial specially by preventing the risk of developing complications.

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    H, K., & BP, S. (2010). Aqueous Extract of Garcinia indica Choisy Restores Glutathione in Type 2 Diabetic Rats. Journal of Young Pharmacists, 2(3), 265-268. https://doi.org/10.4103/0975-1483.66806

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    © 2010 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0