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Antioxidant, Antinociceptive and Anti-inflammatory Activities of Ethanolic Extract of Leaves of Alocasia indica (Schott.)

1★, 2, 1, 3, 4★ Corresponding author

  1. 1Government College of Pharmacy, Vidyanagar, Karad, INDIA.
  2. 2Allana College of Pharmacy, Pune, INDIA.
  3. 3Rajarambapu College of Pharmacy, Kasegaon, Taluka, Walwa District, Sangli- 415404, Maharashtra, INDIA.
  4. 4MAEER’s Maharashtra Institute of Pharmacy, Kothrud, Pune, INDIA.

CORRESPONDENCE

Mulla WA

Government College of Pharmacy, Vidyanagar, Karad, INDIA.

wahidmulla@gmail.com

Volume 2, Issue 2 · pp. 137-14 · 2010 · DOI: 10.4103/0975-1483.63152

ABSTRACT

Extracts obtained from the leaves of various Alocasia species have been used in India as folk remedy for the treatment of various inflammatory ailments including rheumatism and bruise. The ethanolic extract of leaves of Alocasia indica Schott. was evaluated by using different in vitro antioxidant models of screening like scavenging of 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical, nitric oxide radical, superoxide anion radical, and hydroxyl radical. The antinociceptive activity was tested by acetic acid-induced writhing response, hot plate method, and tail flick method in albino rats. The anti-inflammatory potential of gels of ethanolic extract has been determined by using carrageenan-induced paw edema assay, formalin-induced paw edema assay, arachidonic acid-induced ear edema assay, and xylene-induced ear edema assay. The extract showed remarkable antioxidant activity in all models, comparable to the standard reference drug ascorbic acid. The ethanolic extract of Alocasia indica and its gels produced dose-dependent antinociceptive and anti-inflammatory activity, respectively. This finding suggests that ethanolic extract of A. indica possess potent antinociceptive and anti-inflammatory activity possibly due to its free radical scavenging properties.

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    WA, M., SB, K., VS, T., AR, C., & BS, K. (2010). Antioxidant, Antinociceptive and Anti-inflammatory Activities of Ethanolic Extract of Leaves of Alocasia indica (Schott.). Journal of Young Pharmacists, 2(2), 137-14. https://doi.org/10.4103/0975-1483.63152

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    © 2010 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0