Investigation of Possible Role of the PAR-2 Receptor in Intestinal Inflammation
1, 2★, 3★ Corresponding author
- 1Department of Pharmacology, 1Shree Sarvajanik Pharmacy College, Mahesana, INDIA.
- 2C.K.Pithawalla Institute of Pharmaceutical Science and Research, Surat, Gujarat, INDIA.
- 3K.B. Institute of Pharmaceutical Education and Research, GH-6, Sector 23, Gandhinagar, Gujarat, INDIA.
CORRESPONDENCE
Patel MA
C.K.Pithawalla Institute of Pharmaceutical Science and Research, Surat, Gujarat, INDIA.
Volume 2, Issue 1 · pp. 54-58 · 2010 · DOI: 10.4103/0975-1483.62214
ABSTRACT
The present study was undertaken to study the role of PAR-2 receptor activation in pathophysiology of intestinal inflammation. Inflammatory bowel disease was induced in Wistar albino rats by intrarectal administration of 2, 4, 6 trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on 1st day only). Trypsin (500 mg/kg, 1 mg/kg, 5 mg/kg, intrarectal) was given from the same day up to 20 days. Various physical parameters including body weight, food and water intake were measured on 1st and 20th days. At end of the experiment, colon weight and various histopathological indexes were assessed. The colon homogenate malondialdehyde (MDA), myeloperoxidase (MPO), and superoxide dismutase (SOD) and % mast cell protection in mesentery were also measured. Trypsin at higher dose (5 mg/kg) showed the higher level of oxidative enzymes and lower level of protective enzymes as compared to the animals treated with only TNBS. Trypsin treatment produced significantly more mast cell degranulation. Finally in the histopathology, there was increased in severity of the disease in trypsin-treated animals. The role of PAR-2 (protease activated receptor-2) receptor in gut is pro‑inflammatory and thus appears as a new potential therapeutic target for inflammatory bowel disease treatments.
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MB, P., MA, P., & GB, S. (2010). Investigation of Possible Role of the PAR-2 Receptor in Intestinal Inflammation. Journal of Young Pharmacists, 2(1), 54-58. https://doi.org/10.4103/0975-1483.62214
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