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Zinc Oxide Nanoparticles for their Anti-Convulsant Property: A Comprehensive Review

1, 1★, 1, 1, 1★ Corresponding author

  1. 1Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B G Nagar, Karnataka, INDIA.

CORRESPONDENCE

Bharathi Doddla Raghunathanaidu

Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B G Nagar, Karnataka, INDIA.

pharmacology.saccp@accp.co.in

Received: 08-07-2024; Revised: 20-10-2024; Accepted: 30-11-2024.

Volume 17, Issue 1 · pp. 46-53 · 2025 · DOI: 10.5530/jyp.20251354

ABSTRACT

Zinc Oxide Nanoparticles (ZnO NPs) have garnered interest for their potential anti-convulsant properties, offering a promising approach to epilepsy treatment. Their unique physicochemical traits, such as a large surface area and inherent antioxidant capacities, make ZnO NPs potent inhibitors of oxidative stress, a key factor in epileptogenesis. Experimental models have shown that ZnO NPs can reduce Reactive Oxygen Species (ROS) levels and protect against brain injury. By influencing neurotransmitter release, including glutamate and GABA, ZnO NPs help maintain the excitatory-inhibitory balance in the brain, potentially reducing seizure likelihood. Their nanoscale size facilitates effective blood-brain barrier crossing, enhancing the bioavailability of traditional anti-convulsant medications and boosting their therapeutic effects. ZnO NPs offer neuroprotection by regulating calcium influx and preserving neuronal membranes, defending neurons against excitotoxicity, common in seizures. Additionally, they enhance drug delivery by acting as carriers, increasing the bioavailability of standard anti-epileptic drugs and potentially improving treatment outcomes while minimizing side effects. In conclusion, ZnO NPs antioxidant properties, neurotransmission modulation, and drug delivery capabilities position them as a promising adjunct therapy for epilepsy. Further research is essential to maximize their therapeutic potential and ensure safety.

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    Venkatesh, A., Raghunathanaidu, B. D., Kumar, C., Manchegowda, J. B., & Ahmed, S. S. (2025). Zinc Oxide Nanoparticles for their Anti-Convulsant Property: A Comprehensive Review. Journal of Young Pharmacists, 17(1), 46-53. https://doi.org/10.5530/jyp.20251354

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    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0