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Autoimmune Unraveling: Phenobarbital-Associated Pemphigus Vulgaris Case Report

1, 1★, 2, 2, 2, 1, 1★ Corresponding author

  1. 1Department of Pharmacy Practice, KLE College of Pharmacy, Vidyanagar, Hubballi. A Constituent Unit of KLE Academy of Higher Education and Research, Belagavi, Karnataka, INDIA.
  2. 2PharmD Interns, KLE College of Pharmacy, Vidyanagar, Hubballi. A Constituent Unit of KLE Academy of Higher Education and Research, Belagavi, Karnataka, INDIA.

CORRESPONDENCE

Sanatkumar Bharamu Nyamagoud

Department of Pharmacy Practice, KLE College of Pharmacy, Vidyanagar, Hubballi. A Constituent Unit of KLE Academy of Higher Education and Research, Belagavi, Karnataka, INDIA.

dr.sanathnyamagoud@gmail.com

Received: 21-02-2024; Revised: 01-03-2024; Accepted: 05-05-2024.

Volume 16, Issue 3 · pp. 597-600 · 2024 · DOI: 10.5530/jyp.2024.16.75

ABSTRACT

This case report presents the clinical scenario of a 22 years old female patient with decade long history of seizure disorder and is on chronic anti-seizure management therapy. The patient’s initial symptoms manifested as lesions over the oral cavity, over the period of time the lesions progressed to scalp, chest and buttocks. Pemphigus is a rare heterogeneous group of autoimmune disease that affects the skin and the mucous membrane. A combination of inappropriate activation of host B lymphocytes producing intracellular ImmunoglobulinG antibodies and biochemical interactions results in the drug-induced pemphigus. Acantholypsia is the term for the process by which these auto antibodies target the desmogleins and split the cells in the epidermis. This case emphasizes the requisite for further research on understanding the effect of anti-seizure therapy.

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    Acharya, P., Nyamagoud, S. B., Netalakar, A., Umarani, T. J., Hiremath, N., M, D. B., & Swamy, A. H. V. (2024). Autoimmune Unraveling: Phenobarbital-Associated Pemphigus Vulgaris Case Report. Journal of Young Pharmacists, 16(3), 597-600. https://doi.org/10.5530/jyp.2024.16.75

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    © 2024 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0