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Evaluation of the Effects of Propolis and Xylitol Chewable Tablets on the Salivary Concentrations of Oral Micro-organisms in Orthodontic Patients: A Pilot Study

1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 4, 3, 5, 6, 7, 8, 8★★ Corresponding author

  1. 1Veterinary Medicine School, State University of Ceara, Fortaleza, CE, BRAZIL.
  2. 2Health Multidisciplinary Residence Program, Public Health School from Ceara State, Fortaleza, CE, BRAZIL.
  3. 3Pharmacy College, Catholic University Center of Quixadá, Quixadá, CE, BRAZIL.
  4. 4Department of Health Sciences, Division of Microbiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, SP, BRAZIL.
  5. 5Dentistry College, Unichristus University Center, Fortaleza, CE, BRAZIL.
  6. 6Pharmacy College, Unifanor University Center, Fortaleza, CE, BRAZIL.
  7. 7Dentistry Faculty, Arthur Sá Earp Neto University Center, Petropolis, RJ, BRAZIL.
  8. 8Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, CE, BRAZIL.

CORRESPONDENCE

Edilson Martins Rodrigues Neto

Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, CE, BRAZIL.

edilsonmrneto@hotmail.com

Received: 20-12-2020; Revised: 09-01-2021; Accepted: 21-01-2021.

Volume 13, Issue 1 · pp. 68-71 · 2021 · DOI: 10.5530/jyp.2021.13.15

ABSTRACT

Objectives: This study sought to evaluate the effectiveness of red propolis and xylitol chewable tablets in reducing concentrations of micro-organisms such as Streptococcus mutans (SM) and gram-negative bacteria (GNB).Methods: A total of 12 volunteers of both sexes presenting no caries (ICDAS II 0), users of fixed orthodontic appliances and with visible plaque index were randomly assigned to one of two groups. Was to determine the variations in the concentrations of SM and GNB in the saliva before and after the administration of the chewable tablets. The appearance of adverse reactions and side effects was analyzed. The Mann-Whitney (parametric) test was used for pairwise comparisons of means. The Wilxocon test was also used.Results:The study revealed that the propolis and xylitol chewable tablets had antimicrobial activity, reducing the concentration of GNB by -1.39 log10 CFU/mL (p = 0.036) and compared to placebo (p = 0.004698). There was a significant reduction of SM of -0.22 log10 CFU/mL (p = 0.031) and compared to placebo (p = 0.002165).Conclusion: Thus, in addition to the good safety profile, with a low rate of adverse effects, red propolis and xylitol tablets proved to be an effective potential low-cost alternative to combat dental caries and other periodontal diseases.

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    Siqueira, É. C., Campos, F. M. T., Mendes, J. C., Lima, L. N. D., Araújo, R. S., Gomes, N. K. S., Lima, L. R. D. S., Nogueira, R. F., Rocha, M. C. D. S., Barros, R. J. V., Bandeira, C. E. M., Sales, J. P. D., Fraga, E. G. D. S., Nogueira, L. D. S., Meneses, C. A. O., Albuquerque, R. L. D., Calcia, T. B. B., Lobo, P. L. D., & Neto, E. M. R. (2021). Evaluation of the Effects of Propolis and Xylitol Chewable Tablets on the Salivary Concentrations of Oral Micro-organisms in Orthodontic Patients: A Pilot Study. Journal of Young Pharmacists, 13(1), 68-71. https://doi.org/10.5530/jyp.2021.13.15

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    © 2021 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0