Journal of Young Pharmacists logo
Submit
Journal of Young PharmacistsACADEMIC PUBLISHING
Article

Formulation and in vitro Evaluation of Floating Tablets of Dicloxacillin Sodium Using Different Polymers

1★, 1, 1, 3, 2★ Corresponding author

  1. 1Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh, INDIA.
  2. 2Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh, INDIA.
  3. 3Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education & Research, Anantapur, Andhra Pradesh, INDIA.

CORRESPONDENCE

Haranath Chinthaginjala

Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh, INDIA.

haranathriper@gmail.com

Received: 06-05-2019; Revised: 23-06-2019; Accepted: 26-06-2019.

Volume 11, Issue 3 · pp. 247-253 · 2019 · DOI: 10.5530/jyp.2019.11.51

ABSTRACT

Objectives: The purpose of the work was to develop gastro retentive floating tablets of Dicloxacillin sodium using different ratios of HPMC K 100M, Xanthan gum, Guar gum. Sodium bicarbonate is used as a gas generating agent. Dicloxacillin sodium is used to treat a wide variety of bacterial infections and has a half-life of about 2 hr.Methods: Gastro retentive floating tablets containing 270 mg of dicloxacillin sodium were prepared by wet granulation method employing different ratios of polymers.Results: The formulated tablets were evaluated for precompression parameters and were in the acceptable limits. Post-compression parameters such as weight variation, hardness, friability, swelling index, floating lag time and total floating time were also evaluated. The formulation F3 with HPMC K 100M showed 98.87% of drug release at the end of 12 hr, maintained integrity of tablets and have an optimum floating lag time of 90±0.14 sec and total floating time of 12 hr. The optimized formulation F3 was fitted to various kinetic models and the results showed that F3 formulation followed Zero order kinetics with an R2 value of 0.993. The mechanism of drug release from F3 formulation was non-fickian diffusion.Conclusion: The study concluded that, among all the developed formulations, F3 formulation floated up to 12 hr with maximum drug release and can be considered as promising formulation.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Chinthaginjala, H., Barghav, G. C., Reddy, C. M., Pradeepkumar, B., & Ahad, H. A. (2019). Formulation and in vitro Evaluation of Floating Tablets of Dicloxacillin Sodium Using Different Polymers. Journal of Young Pharmacists, 11(3), 247-253. https://doi.org/10.5530/jyp.2019.11.51

    Copyright and licence

    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0