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JYP · Lens · Discovery of a Series of 5-benzylidene-1, 3-thiazolidine-2, 4-dione-linked Chalcone Hybrids as a Novel Class of 5-Lipoxygenase (5-LO) Inhibitors

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Article · Volume 10, Issue 2 · pp. 241-242

Discovery of a Series of 5-benzylidene-1, 3-thiazolidine-2, 4-dione-linked Chalcone Hybrids as a Novel Class of 5-Lipoxygenase (5-LO) Inhibitors

Vasudeva Rao Avupati1, Yuawa Rani2, Ashwinder Singh3

  1. 1Pharmaceutical Chemistry Division, School of Pharmacy, International Medical University, 126, Jln Jalil Perkasa 19, Bukit Jalil, Wilayah Persekutuan, Kuala Lumpur, MALAYSIA.
  2. 2Pharmacology Division, Faculty of Pharmacy, Asia Metropolitan University, G-8 Jalan Kemacahaya 11, Taman Kemacahaya, Cheras, Selangor, MALAYSIA.
  3. 3Pharmaceutical Chemistry Division, Faculty of Pharmacy, Asia Metropolitan University, G-8 Jalan Kemacahaya 11, Taman Kemacahaya, Cheras, Selangor, MALAYSIA.

Abstract

In mammals, lipoxygenases (LOXs) are enzymes containing iron that are biological targets for essential fatty acids. These fatty acids are eico sanoids, derived from arachidonic acid, play important roles in im plication and development of multifactorial inflammatory diseases.

Keywords: Lipoxygenases; Fatty acids; Inflammatory diseases

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