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Design, Evaluation and Study of Effect of Hydrophilic Polymers on Release Rate of Antiulcer Floating Tablets

1★, 1, 1, 1, 2★ Corresponding author

  1. 1Departments of Pharmaceutics, INDIA.
  2. 2Department of Pharmacology, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, INDIA.

CORRESPONDENCE

Akbari BV

Departments of Pharmaceutics, INDIA.

bhavesh_akbari2003@yahoo.com

Volume 1, Issue 4 · pp. 305-311 · 2009 · DOI: 10.4103/0975-1483.59318

ABSTRACT

Gastro retentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. Different approaches for gastro retentive dosage forms include ß oating, raft, expanding/swelling, bioadhesive/ mucoadhesive and high/low density systems.Famotidine, an anti-ulcer drug, suffers from poor bioavailability (50% as famotidine is less soluble in alkaline pH. Famotidine used in combination with antacids promotes local delivery of these drugs to the receptor of the parietal cell wall. Local delivery also increases bioavailability at the stomach wall receptor site and increases the efÞ cacy of drugs to reduce acid secretion. This study aim to formulate ß oating tablets of famotidine using an effervescent approach for gastroretentive drug delivery system. Floating tablets were prepared using direct compression techniques using polymers like HPMC K4M and HPMCK100M for their gel-forming properties. The HPMC polymer alone is unable to control release rate. It releases drug >90% in four to six hours. In combination with Xanthan gum it release >90% in eight hours. The results indicate that gas generated gastroretentive ß oating tablets of famotidine containing HPMCK100M and Xanthan gum provide better options for controlled release action and improved bioavailability.

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    BV, A., RB, D., BG, S., DJ, L., & CS, S. (2009). Design, Evaluation and Study of Effect of Hydrophilic Polymers on Release Rate of Antiulcer Floating Tablets. Journal of Young Pharmacists, 1(4), 305-311. https://doi.org/10.4103/0975-1483.59318

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0