Article · Volume 1, Issue 3 · pp. 284
Ivabradine: Novel If Channel Inhibitor
Ameya H1, Kumar A2
- 1Faculty of Medicine, AIMST University, MALAYSIA.
- 2Unit of Pharmacology, Faculty of Medicine, MALAYSIA.
Abstract
Pacemaker activity of the heart involves interplay between several ionic currents that inß uence spontaneous diastolic depolarization of the sinoatrial node, including If current. The search for pure heart rate-lowering agents to prevent angina without over all adverse effects of β-blockers[1] began more than three decades ago. The discovery of If current and If channels offered a possible approach to the developing pure heart rate-lowering agents.[1]
Keywords: Pacemaker activity; If current; Angina
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