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Protective Effect of Alcoholic Extract of Amla (Emblica offi cinalis) Fruits on Cerebral Reperfusion Injury in Rats

1, 1★, 1, 1, 1★ Corresponding author

  1. 1Department of Pharmacology, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana, Gujarat-384001, INDIA.

CORRESPONDENCE

Patel MB

Department of Pharmacology, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana, Gujarat-384001, INDIA.

manish_pharma2005@yahoo.com

Volume 1, Issue 3 · pp. 213-219 · 2009 · DOI: 10.4103/0975-1483.57067

ABSTRACT

Ischemia-reperfusion injury is a phenomenon whereby cellular damage in a hypoxic organ is accentuated following the restoration of oxygen delivery. Wistar rats of either sex (250-300 g) were treated for 15 days with alcoholic extract of Emblica offi cinalis fruits (250-500mg/kg) prior to ischemic reperfusion. After 15 days ischemia was produced by clamping the right common carotid artery for 25 min and reperfusion for 40 min by unclamping. Brain was dissected out to prepare a homogenate to measure the level of malondialdehyde, superoxide dismutase, catalase, vitamin C and protein estimation. Animals subjected to ischemic reperfusion without any treatment were included as model control and animals treated with vitamin E were included as a standard. Animals subjected to ischemic reperfusion without any treatment showed higher level of oxidative enzymes and lower level of protective enzymes as compared with the animals treated with alcoholic extract of amla fruits. In histopathology, protection against the injury in the animals treated with alcoholic extract of amla fruits was noted.

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    NM, P., MB, P., JV, P., IS, A., & CN, P. (2009). Protective Effect of Alcoholic Extract of Amla (Emblica offi cinalis) Fruits on Cerebral Reperfusion Injury in Rats. Journal of Young Pharmacists, 1(3), 213-219. https://doi.org/10.4103/0975-1483.57067

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0