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Design and in vitro Evaluation of Mucoadhesive Microcapsules of Pioglitazone

1★, 1, 1, 1★ Corresponding author

  1. 1SD College of Pharmacy and Vocational Studies, Bhopa Road, Muzaffarnagar, Uttar Pradesh, INDIA.

CORRESPONDENCE

Singh C

SD College of Pharmacy and Vocational Studies, Bhopa Road, Muzaffarnagar, Uttar Pradesh, INDIA.

pharma_pharm@yahoo.com

Volume 1, Issue 3 · pp. 195-198 · 2009 · DOI: 10.4103/0975-1483.57063

ABSTRACT

Mucoadhesive microcapsules of pioglitazone were prepared using sodium alginate as a shell forming polymer and Carbapol 974, HPMC, Sodium CMC as a mucoadhesive polymer for the potential use of treating acute and chronic diabetes mellitus. Large spherical microcapsules with a coat consisting of sodium alginate and a mucoadhesive polymer could be prepared by oriÞ ce-ionic gelation process. The microcapsules exhibited good mucoadhesive properties and drug release from these mucoadhesive microcapsules was slow and extended over longer periods of time, depending on the composition of the coat. These mucoadhesive microcapsules are, thus, suitable for oral controlled release of pioglitazone.

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    C, S., KA, J., C, K., & K, A. (2009). Design and in vitro Evaluation of Mucoadhesive Microcapsules of Pioglitazone. Journal of Young Pharmacists, 1(3), 195-198. https://doi.org/10.4103/0975-1483.57063

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0